Thousands have gathered in the centre of the capital Cairo, where troops and armoured vehicles are deployed but not seeking to intervene.
Clashes are reported in the cities of Alexandria and Ismailiya.
Health officials say 38 people have died in clashes across Egypt since Friday.
The latest figures bring the death toll in the week's unrest to at least 45, with both protesters and police officers among the dead. About 2,000 people have been injured.
A curfew in Cairo, Alexandria and Suez has been extended to last between the hours of 1600 and 0800 (1400 GMT and 0600 GMT).
The army has advised people to obey the curfew and avoid gathering in groups.
Anyone violating the curfew would be "in danger", it said.
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AT THE SCENE
The streets of this industrial port city are tense but quiet this morning after a night of violence and bloodshed. Local reports say as many as 13 people may have been killed during the hours of darkness.
City police and administrators have fled Suez and the army has moved onto the streets, although there is no real sign that they're in control.
The central police station is a smouldering ruin as are many shops and other businesses with close ties to President Mubarak's regime.
People have told us the protests will continue until every trace of that regime is gone.
Others have threatened us and demanded we stop filming, accusing the US and UK of supporting President Mubarak, and Western media of portraying the demonstrators as criminals and looters.
Hundreds of foreign tourists and Egyptian nationals are at Cairo's main airport seeking flights out of the country, the Associated Press news agency reports.
The agency also says that the Egyptian military has used tanks and armoured personnel carriers to seal off the site of the pyramids on the Giza Plateau. The army had already secured the Egyptian Museum, home to such treasures as the gold mask of King Tutankhamen, to protect it from looters.
Cairo stock exchange will be closed on Sunday - a full trading day in the Middle East - because of the turmoil in the city.
Friday saw tens of thousands on the streets across Egypt in protests that continued into the night, defying a curfew. In Cairo, protesters set fire to the headquarters of the governing NDP party and surrounded state TV and the foreign ministry.
Mr Mubarak responded by sacking his government. In a televised address - his first public comments since the protests began on Tuesday - he also accused the protesters of destabilising the country.
The government has now formally resigned, with reports suggesting that Racheed Mohamad Racheed - current minister of investment, commerce, and industry - will be named as the new prime minister.
Defiance
In Cairo on Saturday, Tahrir Square is again the main focal point for demonstrators, who are shouting anti-Mubarak chants. Mobile phone services have been restored in the city, but the internet remains down.
The BBC's Yolande Knell, in the Egyptian capital, says there is anger that demands for political reforms are not being listened to. She adds that protesters say they will ignore the curfew and stay on the streets until there is change.
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Burned out personnel carrier beside a tank in central Cairo
In Suez, soldiers are on the streets after the city's police and authorities fled following Friday's violence in which the main police station was burned down.
Reports from the northern coastal city of Alexandria and the eastern city of Ismailiya say thousands of protesters are on the streets, with clashes occurring between polices and demonstrators.
And a BBC Arabic producer reports that inmates have rioted in the city of al-Manufiya, north-west of Cairo.
US President Barack Obama, who telephoned President Mubarak on Friday, has said a violent response by the Egyptian authorities will not address the grievances of the people. He urged protesters to desist from violence, and also called on the Egyptian government to stop interfering with the internet, social networking sites and mobile phone services.
White House spokesman Robert Gibbs said Washington would review its aid to Egypt based on events in the coming days. Egypt is the fourth largest recipient of US aid, after Afghanistan, Pakistan and Israel.
Britain, the US and France are all advising against non-essential travel to Egypt.
The unrest in Egypt follows an uprising in Tunisia two weeks ago which toppled President Zine al-Abidine Ben Ali after 23 years in power.
The Tunisian upheaval began with anger over rising food prices, high unemployment and anger at official corruption - problems which have also left many people Egypt feeling frustrated and resentful of their leadership.
Cairo protests
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